


By Ludwig Burger
(Reuters) -Roche's Alzheimer's drug candidate could not be shown to slow dementia progression in two drug trials, leaving rivals Biogen (NASDAQ:BIIB) and Eisai as leaders in a high-stakes race to launch a treatment for the memory-robbing disease.
Roche said in a statement on Monday that twin studies known as Graduate 1 and 2 had not reached their main goal of showing that the drug gantenerumab could preserve abilities such as remembering, solving problems, orientation and personal care in patients suffering from early stages of Alzheimer's disease.
The Swiss drugmaker conducted two identically designed studies, each with about 1,000 participants, who were examined and queried by physicians over more than two years. Within each study, volunteers were randomly assigned to receive either the injectable antibody drug gantenerumab or a placebo.
The drug was associated with a relative reduction in clinical decline of 8% in Graduate 1 and 6% in Graduate 2 compared with the placebo, but those results were not statistically reliable, the company said in a statement.
Credit Suisse analysts, who had seen a 20% chance of the drug reaching peak annual sales of $10 billion, described the trial failure as "unequivocal".
Berenberg analysts had put a 50% probability on gantenerumab achieving the $10 billion peak.
Roche shares fell 4.4% to their lowest in almost seven weeks.
Analysts have said the read-out from the trial would impact stock market confidence in Roche's research prowess, especially after lung cancer immunotherapy hopeful tiragolumab fell through in trials earlier this year, battering the company's shares.
"The development pipeline has disappointed a bit too often to keep the stock on a list of favourites," analysts at Luzerner Kantonalbank said in a research note.
Gantenerumab was designed to bind to aggregated forms of beta-amyloid and remove brain amyloid plaques, which are believed to play a crucial role in the slowly progressing dementia disease.
The setback will be an added challenge for CEO-designate Thomas Schinecker, Roche's head of diagnostics, who will be promoted in March. He will replace Severin Schwan, the chief executive who has led a successful campaign to diversify away from Roche's traditional focus on cancer.
The quest to develop an Alzheimer's drug, targeting beta-amyloid or other molecules, has been beset by a long list of study failures.
But rival Biogen in September scored a surprise trial success with an experimental Alzheimer's drug that it developed with Eisai, rebuilding confidence among industry executives and researchers in the beta-amyloid approach.
Biogen and Eisai said at the time their drug candidate lecanemab had slowed progression of the brain-wasting disease by 27% compared with a placebo in a large trial of patients in the early stages of Alzheimer's.
Roche released only the main outcome of the trials on Monday. It plans to present detailed data at the Clinical Trials on Alzheimer's Disease conference in San Francisco on Nov. 30.
Rachelle Doody, Roche's head of neurodegeneration, said she was very disappointed, adding that trial measures of amyloid removal were also lower than hoped.
“We will be showing that there is a relationship between the lowering of amyloid and the clinical outcomes. It’s just that when you don’t get the amyloid lowering that you expected you won’t get the clinical outcome that you expected," she told Reuters.
DIFFICULT TO DIAGNOSE
Most of the 55 million people suffering from dementia worldwide are likely to be affected by Alzheimer's disease, according to the World Health Organization. In 2030, dementia is expected to affect 78 million.
Alzheimer's is difficult to diagnose, especially during its early stages.
Germany's Morphosys would have received tiered royalties of about 2% to 3% on future gantenerumab sales from its early role in developing the drug. Its shares plunged 28%.
Royalty Pharma would have been entitled to about 3% to 4% of gantenerumab sales under a 2021 deal with Morphosys.
Eli Lilly (NYSE:LLY) is also working on an amyloid-targeting antibody drug, donanemab, with results of a key late-stage trial expected by mid-2023.
EUR/USD
1.0658
-0.0008 (-0.07%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (2)
Sell (3)
EUR/USD
1.0658
-0.0008 (-0.07%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (2)
Sell (3)
GBP/USD
1.2475
-0.0015 (-0.12%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (10)
USD/JPY
157.91
+0.12 (+0.07%)
Summary
↑ BuyMoving Avg:
Buy (12)
Sell (0)
Indicators:
Buy (9)
Sell (0)
AUD/USD
0.6469
-0.0003 (-0.05%)
Summary
NeutralMoving Avg:
Buy (10)
Sell (2)
Indicators:
Buy (2)
Sell (3)
USD/CAD
1.3780
+0.0003 (+0.03%)
Summary
↑ BuyMoving Avg:
Buy (12)
Sell (0)
Indicators:
Buy (7)
Sell (0)
EUR/JPY
168.32
+0.10 (+0.06%)
Summary
↑ BuyMoving Avg:
Buy (12)
Sell (0)
Indicators:
Buy (9)
Sell (0)
EUR/CHF
0.9808
+0.0001 (+0.01%)
Summary
NeutralMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (3)
Sell (2)
Gold Futures
2,295.80
-7.10 (-0.31%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (9)
Silver Futures
26.677
+0.023 (+0.09%)
Summary
↑ SellMoving Avg:
Buy (2)
Sell (10)
Indicators:
Buy (0)
Sell (9)
Copper Futures
4.5305
-0.0105 (-0.23%)
Summary
↑ BuyMoving Avg:
Buy (10)
Sell (2)
Indicators:
Buy (8)
Sell (1)
Crude Oil WTI Futures
81.14
-0.79 (-0.96%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (1)
Sell (7)
Brent Oil Futures
85.62
-0.71 (-0.82%)
Summary
↑ SellMoving Avg:
Buy (1)
Sell (11)
Indicators:
Buy (1)
Sell (7)
Natural Gas Futures
1.946
-0.009 (-0.46%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (5)
US Coffee C Futures
213.73
-13.77 (-6.05%)
Summary
↑ SellMoving Avg:
Buy (3)
Sell (9)
Indicators:
Buy (0)
Sell (10)
Euro Stoxx 50
4,920.55
-60.54 (-1.22%)
Summary
↑ SellMoving Avg:
Buy (4)
Sell (8)
Indicators:
Buy (1)
Sell (7)
S&P 500
5,035.69
-80.48 (-1.57%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (7)
DAX
17,921.95
-196.37 (-1.08%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (1)
Sell (6)
FTSE 100
8,144.13
-2.90 (-0.04%)
Summary
SellMoving Avg:
Buy (5)
Sell (7)
Indicators:
Buy (2)
Sell (4)
Hang Seng
17,763.03
+16.12 (+0.09%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (1)
Sell (6)
US Small Cap 2000
1,973.05
-42.98 (-2.13%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (7)
IBEX 35
10,854.40
-246.40 (-2.22%)
Summary
NeutralMoving Avg:
Buy (6)
Sell (6)
Indicators:
Buy (3)
Sell (3)
BASF SE NA O.N.
49.155
+0.100 (+0.20%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (1)
Sell (7)
Bayer AG NA
27.35
-0.24 (-0.87%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (8)
Allianz SE VNA O.N.
266.60
+0.30 (+0.11%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (3)
Sell (5)
Adidas AG
226.40
-5.90 (-2.54%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (2)
Sell (7)
Deutsche Lufthansa AG
6.714
-0.028 (-0.42%)
Summary
NeutralMoving Avg:
Buy (3)
Sell (9)
Indicators:
Buy (9)
Sell (1)
Siemens AG Class N
175.90
-1.74 (-0.98%)
Summary
↑ SellMoving Avg:
Buy (0)
Sell (12)
Indicators:
Buy (0)
Sell (9)
Deutsche Bank AG
15.010
-0.094 (-0.62%)
Summary
NeutralMoving Avg:
Buy (4)
Sell (8)
Indicators:
Buy (6)
Sell (2)
EUR/USD | 1.0658 | ↑ Sell | |||
GBP/USD | 1.2475 | ↑ Sell | |||
USD/JPY | 157.91 | ↑ Buy | |||
AUD/USD | 0.6469 | Neutral | |||
USD/CAD | 1.3780 | ↑ Buy | |||
EUR/JPY | 168.32 | ↑ Buy | |||
EUR/CHF | 0.9808 | Neutral |
Gold | 2,295.80 | ↑ Sell | |||
Silver | 26.677 | ↑ Sell | |||
Copper | 4.5305 | ↑ Buy | |||
Crude Oil WTI | 81.14 | ↑ Sell | |||
Brent Oil | 85.62 | ↑ Sell | |||
Natural Gas | 1.946 | ↑ Sell | |||
US Coffee C | 213.73 | ↑ Sell |
Euro Stoxx 50 | 4,920.55 | ↑ Sell | |||
S&P 500 | 5,035.69 | ↑ Sell | |||
DAX | 17,921.95 | ↑ Sell | |||
FTSE 100 | 8,144.13 | Sell | |||
Hang Seng | 17,763.03 | ↑ Sell | |||
Small Cap 2000 | 1,973.05 | ↑ Sell | |||
IBEX 35 | 10,854.40 | Neutral |
BASF | 49.155 | ↑ Sell | |||
Bayer | 27.35 | ↑ Sell | |||
Allianz | 266.60 | ↑ Sell | |||
Adidas | 226.40 | ↑ Sell | |||
Lufthansa | 6.714 | Neutral | |||
Siemens AG | 175.90 | ↑ Sell | |||
Deutsche Bank AG | 15.010 | Neutral |
Mua/Bán 1 chỉ SJC # So hôm qua # Chênh TG | |
---|---|
SJC Eximbank | 8,300/ 8,500 (8,300/ 8,500) # 1,298 |
SJC 1L, 10L, 1KG | 8,300/ 8,520 (0/ 0) # 1,510 |
SJC 1c, 2c, 5c | 7,380/ 7,550 (0/ 0) # 540 |
SJC 0,5c | 7,380/ 7,560 (0/ 0) # 550 |
SJC 99,99% | 7,370/ 7,470 (0/ 0) # 460 |
SJC 99% | 7,196/ 7,396 (0/ 0) # 386 |
Cập nhật 01-05-2024 10:45:19 | |
Xem lịch sử giá vàng SJC: nhấn đây! |
ↀ Giá vàng thế giới | ||
---|---|---|
$2,285.72 | -47.5 | -2.04% |
ʘ Giá bán lẻ xăng dầu | ||
---|---|---|
Sản phẩm | Vùng 1 | Vùng 2 |
RON 95-V | 25.440 | 25.940 |
RON 95-III | 24.910 | 25.400 |
E5 RON 92-II | 23.910 | 24.380 |
DO 0.05S | 20.710 | 21.120 |
DO 0,001S-V | 21.320 | 21.740 |
Dầu hỏa 2-K | 20.680 | 21.090 |
ↂ Giá dầu thô thế giới | |||
---|---|---|---|
WTI | $80.83 | +3.39 | 0.04% |
Brent | $85.50 | +3.86 | 0.05% |
$ Tỷ giá Vietcombank | ||
---|---|---|
Ngoại tệ | Mua vào | Bán ra |
USD | 25.088,00 | 25.458,00 |
EUR | 26.475,36 | 27.949,19 |
GBP | 30.873,52 | 32.211,36 |
JPY | 156,74 | 166,02 |
KRW | 15,92 | 19,31 |
Cập nhật lúc 10:45:15 01/05/2024 Xem bảng tỷ giá hối đoái |