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AstraZeneca, Ionis eye U.S. approval after positive trial data

LONDON (Reuters) -An interim analysis of AstraZeneca (NASDAQ:AZN) and partner Ionis Pharmaceuticals (NASDAQ:IONS)' eplontersen showed the experimental drug met the main goals in a...
AstraZeneca, Ionis eye U.S. approval after positive trial data © Reuters. FILE PHOTO: The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, U.S., March 22, 2021. REUTERS/Rachel Wisniewski/File Photo

LONDON (Reuters) -An interim analysis of AstraZeneca (NASDAQ:AZN) and partner Ionis Pharmaceuticals (NASDAQ:IONS)' eplontersen showed the experimental drug met the main goals in a late-stage trial in patients with a rare, fatal disease, the Anglo-Swedish drugmaker said on Tuesday.

Based on the results, the companies plan to file an application to market the therapy in the United States later this year in patients with hereditary transthyretin-mediated amyloid polyneuropathy (ATTRv-PN).

The disease - which affects an estimated 40,000 patients globally - leads to peripheral nerve damage with motor disability within five years of diagnosis and, without treatment, is generally fatal within a decade, according to AstraZeneca.

The Cambridge, UK-based company agreed to pay California-based Ionis $200 million upfront, with up to $485 million in conditional payments following regulatory approvals as well as up to $2.9 billion in sales-related milestone payments in a deal to jointly develop and commercialise the drug last year.

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30-06-2022 20:35:02 (UTC+7)

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 EUR/USD1.0419↑ Buy
 GBP/USD1.2159↑ Buy
 USD/JPY135.82↑ Sell
 AUD/USD0.6912Buy
 USD/CAD1.2897↑ Buy
 EUR/JPY141.51Sell
 EUR/CHF0.9954↑ Sell
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 Brent Oil110.93↑ Sell
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 Euro Stoxx 503,430.55↑ Sell
 S&P 5003,767.83↑ Sell
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 FTSE 1007,141.00↑ Sell
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