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Analysis - U.S. looks to COVID-19 boosters to curb virus spread

By Julie Steenhuysen CHICAGO (Reuters) - U.S. officials preparing to roll out COVID-19 booster shots in the face of waning vaccine protection and surging hospitalizations and...
Analysis - U.S. looks to COVID-19 boosters to curb virus spread © Reuters. FILE PHOTO: A person receives a dose of the Pfizer-BioNTech vaccine for the coronavirus disease (COVID-19), at a mobile inoculation site in the Bronx borough of New York City, New York, U.S., August 18, 2021. REUTERS/David 'Dee' Delgado/File Photo

By Julie Steenhuysen

CHICAGO (Reuters) - U.S. officials preparing to roll out COVID-19 booster shots in the face of waning vaccine protection and surging hospitalizations and deaths caused by the highly contagious Delta variant are hoping they might prevent mild cases as well.

In theory, that could reduce virus transmission - a goal officials have been less explicit about - and hasten America's recovery.

“It is not the primary reason (for boosters), but it could actually be a very positive offshoot," Dr. Anthony Fauci, one of the Biden Administration's COVID-19 advisers and the nation’s top infectious disease doctor told Reuters.

The main reason for boosters, Fauci said in a telephone interview, is to reverse the trend of rising "breakthrough" infections among people who are fully vaccinated, a point that many experts dispute.

Available data has shown that most severe breakthrough cases have occurred in people over 65 or among those who are immunocompromised. That latter group is already recommended for a third dose.

Dr. Larry Corey, a virologist at Seattle's Fred Hutchinson Cancer Center who is overseeing the U.S.-government backed COVID-19 vaccine trials, is a proponent of using booster doses to bolster antibody levels enough to prevent infection.

"If you don't get infected, you're not going to transmit it to others, and we will more effectively abort the epidemic, and that has economic benefits," Corey said.

The problem there, many experts point out, is that there is scant scientific evidence showing that boosters will in fact prevent infections and transmission.

Some government studies have shown that when infected with the Delta variant, fully vaccinated people can transmit the virus, mostly to unvaccinated people.

"If you take a look at the evidence from the United States, it is very clear that protection against infection and mildly to moderately symptomatic disease is diminishing," Fauci said.

It is happening among many of the U.S. study populations – including a recent study https://www.reuters.com/business/healthcare-pharmaceuticals/covid-19-vaccines-hold-strong-against-delta-protection-waning-older-adults-2021-09-10 of 600,000 COVID-19 cases in 13 states and large cities. “Not dramatically, but enough," he said.

'WHAT'S THE GOAL?'

While some 63% of eligible people in the United States are fully vaccinated, the Delta variant has caused a surge in the deadly disease among the unvaccinated.

The two most widely used vaccines in the United States – those based on messenger RNA (mRNA) technology made by Pfizer Inc (NYSE:PFE) with BioNTech SE (NASDAQ:BNTX) and Moderna (NASDAQ:MRNA) Inc – are highly effective but less so against Delta. Cases are rising among the vaccinated - including some that result in hospitalization and death.

The U.S. Food and Drug Administration will release data on a possible booster shot on Wednesday morning ahead of a Friday meeting of its vaccine advisory panel. It will include a briefing on the impact of boosters in Israel https://www.reuters.com/world/middle-east/israel-present-covid-19-booster-shot-data-fda-experts-2021-09-05, where the government has closely tracked recipients of the Pfizer/BioNTech shot.

During weekly White House COVID-19 briefings, U.S. Centers for Disease Control and Prevention (CDC) Director Dr. Rochelle Walensky, White House COVID-19 Response Coordinator Jeffrey Zients and Fauci have expressed concern that waning immunity against mild, symptomatic COVID-19 could lead to reduced protection against severe disease, hospitalization and death, pointing to data from Israel.

Other countries that have started or are planning booster programs, including Israel - and in the U.K. for people over 50 - have been more frank about the goal to reduce transmission.

Debate over booster doses in the United States has become a sore point for virologists, who largely remain unconvinced that the vaccines are losing their ability to prevent severe disease and hospitalization.

This week, an article in the journal Lancet by two departing FDA vaccine experts and senior scientists at the World Health Organization, challenged the rationale for booster doses https://www.reuters.com/world/us/covid-19-vaccine-boosters-not-widely-needed-top-fda-who-scientists-say-2021-09-13, saying more evidence is needed to justify their widespread use and that most cases of COVID-19 are spread by the unvaccinated.

Dr. Paul Offit, an infectious disease expert at the University of Pennsylvania and a member of the FDA' vaccine advisory panel, is unconvinced by arguments that boosters are needed just yet.

“The question is, what's the goal? If the goal of the third dose is to enhance protection against serious illness, there's no evidence that that's a problem," Offit said. If the goal is to increase levels of neutralizing antibodies with the aim of decreasing asymptomatic or mild cases, “then we should see those data.”

Corey said the bar for proving a vaccine prevents disease transmission is high.

"Is there proof today? No, but there is every reason to believe that this is possible, and may be beneficial," he said.

Fauci, however, said Israeli data shows that since the booster campaign started, the country has started seeing a decline in the virus’ reproduction number, which represents how many other people a person will COVID-19 is likely to infect. The more immunity in a population, the lower the reproduction number.

Fauci said he is confounded by arguments from vaccine experts that boosters are only needed when vaccines stop preventing severe disease, hospitalization and death.

“What is the magic, mystical issue about hospitalization? I don’t understand that," he said. "What we’re really saying is we don’t care about anything except keeping people out of the hospital. Really? You’re kidding.”

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22-09-2021 08:40:41 (UTC+7)

EUR/USD

1.1729

+0.0006 (+0.05%)

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↑ Buy

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EUR/USD

1.1729

+0.0006 (+0.05%)

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GBP/USD

1.3673

+0.0014 (+0.11%)

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USD/JPY

109.42

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AUD/USD

0.7261

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USD/CAD

1.2781

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EUR/JPY

128.35

+0.32 (+0.25%)

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EUR/CHF

1.0839

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Gold Futures

1,776.15

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Silver Futures

22.735

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Copper Futures

4.2032

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Crude Oil WTI Futures

71.23

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Brent Oil Futures

75.06

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Natural Gas Futures

4.835

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US Coffee C Futures

183.70

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Euro Stoxx 50

4,097.51

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S&P 500

4,354.18

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DAX

15,348.53

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FTSE 100

6,980.98

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Hang Seng

24,221.54

+122.40 (+0.51%)

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Neutral

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US Small Cap 2000

2,190.36

+8.15 (+0.37%)

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↑ Sell

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IBEX 35

8,756.00

+100.60 (+1.16%)

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BASF SE NA O.N.

62.280

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Bayer AG NA

45.70

+0.47 (+1.04%)

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Allianz SE VNA O.N.

187.45

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Adidas AG

281.90

+1.38 (+0.49%)

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Deutsche Lufthansa AG

8.377

-0.287 (-3.31%)

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Siemens AG Class N

145.32

+3.06 (+2.15%)

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Deutsche Bank AG

10.095

-0.135 (-1.32%)

Summary

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Sell (3)

 EUR/USD1.1729↑ Buy
 GBP/USD1.3673↑ Buy
 USD/JPY109.42Neutral
 AUD/USD0.7261↑ Buy
 USD/CAD1.2781↑ Sell
 EUR/JPY128.35Neutral
 EUR/CHF1.0839Neutral
 Gold1,776.15↑ Buy
 Silver22.735↑ Buy
 Copper4.2032↑ Buy
 Crude Oil WTI71.23↑ Buy
 Brent Oil75.06↑ Buy
 Natural Gas4.835↑ Buy
 US Coffee C183.70↑ Buy
 Euro Stoxx 504,097.51↑ Buy
 S&P 5004,354.18↑ Sell
 DAX15,348.53↑ Buy
 FTSE 1006,980.98↑ Buy
 Hang Seng24,221.54Neutral
 Small Cap 20002,190.36↑ Sell
 IBEX 358,756.00Neutral
 BASF62.280↑ Sell
 Bayer45.70↑ Buy
 Allianz187.45↑ Buy
 Adidas281.90↑ Sell
 Lufthansa8.377↑ Sell
 Siemens AG145.32↑ Sell
 Deutsche Bank AG10.095Buy
Mua/Bán 1 chỉ SJC
# So hôm qua # Chênh TG
SJC Eximbank5,660/ 5,710
(10/ 10) # 820
SJC HCM5,650/ 5,715
(5/ 5) # 826
SJC Hanoi5,650/ 5,717
(5/ 5) # 828
SJC Danang5,650/ 5,717
(5/ 5) # 828
SJC Nhatrang5,650/ 5,717
(5/ 5) # 828
SJC Cantho5,650/ 5,717
(5/ 5) # 828
Cập nhật 22-09-2021 08:40:43
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Sản phẩmVùng 1Vùng 2
RON 95-IV2149021910
RON 95-II,III2139021810
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DO 0.05S1602016340
DO 0,001S-V1637016690
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Brent$75.06-0.94-1.26%
$ Tỷ giá Vietcombank
Ngoại tệMua vàoBán ra
USD22.630,0022.860,00
EUR26.007,0827.360,60
GBP30.295,3831.561,13
JPY203,28215,04
KRW16,6220,24
Cập nhật lúc 08:36:00 22/09/2021
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